• The Virtual Physiological Human (VPH) initiative
    September 05, 2014

    The Virtual Physiological Human (VPH) initiative The Virtual Physiological Human (VPH) initiative is a worldwide effort to develop next-generation computer technologies to integrate all information available for each patient, and generated computer models capable of predicting how the health of that patient will evolve under certain conditions. In this video Professor Professor Marco Viceconti provides an overview of the Virtual Physiological Human (VPH) initiative to the audience at TEDxSheffield 2012. ... read more

  • Sustaining the Nation’s Innovation Ecosystems, Information Technology Manufacturing and Competitiveness
    August 18, 2014

    Here is an interesting report from 2004 prepared by the President's Council of Advisors on Science and Technology (PCAST). The report is titled Sustaining the Nation’sInnovation Ecosystems, Information Technology Manufacturing and Competitiveness and can be downloaded from this link: pcast-04-itreport.pdf Executive Summary Overview This Report contains PCAST’s recommendations to the President on sustaining thenation’s innovation ecosystems. PCAST submits the Report to help maintain the United States’global high technology preeminence, and our associated economic prosperity and high standardsof living, for years to come. Almost sixty years ago, Vannevar Bush’s letter to President Truman help... read more

  • How Computers Are Changing Biology
    April 28, 2014

    How Computers Are Changing Biology May 2014 Communications of the ACM It just makes sense. At no other time in our history have we had such easy access to so much data - data that is reflective of both the individual and the population. This fact is true at the sub-individual level - our own biology. There is ample opportunity to discover new and exciting things about what makes us tick, biologically, using computer modeling and data analytics. From the article: It is no secret that computer modeling is changing science. The ability to extract meaningful information from huge data sets and build sophisticated models is altering everything from astronomy to quantum physics. Yet, perhaps no d... read more

  • New RAND Corporation Report: Redirecting Innovation in U.S. Health Care
    April 28, 2014

    Redirecting Innovation in U.S. Health Care Options to Decrease Spendingand Increase Value Download here . From the report: A leading cause of high and growing spending is new medical technologies. Previousstudies aimed at reining in spending considered changing the ways in which existingtechnologies are used. Our work for this project focused on identifying promisingpolicy options to change which medical technologies are created in the first place, withthese two related policy goals: Reduce total health care spending with the smallest possible loss of healthbenefits. Ensure that new medical products that increase spending are accompanied byhealth benefits that are worth the spending increas... read more

  • Go Big Data, Go! Big Data Approach to Bioinformatics Profiling Identifies New Mammalian Clock Gene
    April 24, 2014

    From Scientific Computing Over the last few decades researchers have characterized a set of clock genes that drive daily rhythms of physiology and behavior in all types of species, from flies to humans. Over 15 mammalian clock proteins have been identified, but researchers surmise there are more. A team from the Perelman School of Medicine at the University of Pennsylvania wondered if big-data approaches could find them. To accelerate clock-gene discovery, the investigators, led by John Hogenesch, PhD , professor of Pharmacology and first author Ron Anafi, MD, PhD , an instructor in the department of Medicine, used a computer-assisted approach to identify and rank candidate clock components... read more